Bio-K-Forte by Biotics Research 60 ct
Vitamink2mk7
RRP $29.00
$24.50 inc. tax
Bio-K-Forte by Biotics Research 60 ct Summary

Bio-K-Forte by Biotics Research 60 ct

Combination of vitamin K1 and vitamin K2‚ targeting different tissues in the body.

Two forms of vitamin K are naturally occurring; vitamin K1, known as phylloquinone and vitamin K2, referred to as menaquionone. K1 and K2 differ in their structural
arrangement, with K1 compounds possessing a saturated side chain, while the K2 family of compounds has an unsaturated side chain.(1) In addition to their structural differences, they also target different tissues.(2) The K1 family of compounds (phylloquinones), synthesized
in green leafy vegetables and in plant leaves,(3) is the primary dietary source of vitamin K, estimated to contribute about 40-50% of the total dietary intake. Alternative
sources of phylloquinones include meals prepared with phylloquinone-rich oils such as soybean, cottonseed, canola and olive oils, estimated to contribute ~15% of the dietary
phylloquinine intake.(4) In relation to health, the phylloquinines are typically associated with bone mineralization. Subobtimal levels are correlated to an increase in both osteoporotic
fracture rates and osteoporosis. The former has been correlated with a more “Westernized” lifestyle, which is typically high in protein. Consequently, as a result of a high
protein diet, an increase in the net renal acid excretion has been observed, which in turn increases the excretion of urinary calcium.(5) Even in healthy individuals it has been observed that there is a substantial fraction of undercarboxylated or incompletely carboxylated species of osteocalcin and matrix Gla protein (MGP) in circulation, indicating a quantifiable deficiency in vitamin K.(7) In a study by Rejnmark L., et al., it was noted there was no effect on the bone mineral density (BMD) of the femoral neck or lumbar spine, with a vitamin K intake of 60 mcg/day. A separate study, utilizing a high phylloquinine intake, demonstrated a greater reduction in the percent of underconverted osteocalcin (P<0.05) with high dose supplementation (1000-2000 ug/day phylloquinine, compared to 500µg/day), implicating that a high intake was needed for the conversion of osteocalcin. This in turn may indicate the likelihood that the current daily reference intake (DRI) is too
low to support the carboxylation of osteocalcin.(6) Added to Bio-K Forte Caps®
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
LIT-104 Rev. 08/16 ©Copyright 2016 the likelihood of a low dietary intake
is the fact that phylloquinine is extensively catabolized in the liver.
Subsequently, it has both a quick turnover rate, and a rapid depletion
rate. This fact combined with the extensive loss due to excretion,
suggests that a continual daily supply is appropriate to support bone maintenance.
Menaquinones, collectively referred to as vitamin K2, are structurally defined by their content of isoprene units. Those of dietary relevance have from four
(MK-4) through ten (MK-10) isoprenoid residues.(7) Unlike phylloquinones, menaquinones are present in both human and animal tissues, and are largely synthesized by the gut
microflora. Overall they contribute only a very small portion to the daily vitamin K supply, except in cultures consuming large amounts of fermented soybean products, which contains
significant amounts of MK-6 and MK-8.(8,9) Vitamin K2 is associated with beneficial cardiovascular attributes, and is believed to suppress arterial calcification
via γ-carboxylation of matrix glutamic acid residues.(10) Vascular calcification is considered a major complication in cardiovascular disease, as well as an independent risk
factor for both myocardial infarction and ultimately death.(11) Experimental inactivation of MGP by treatment with a vitamin K antagonist has been demonstrated to result in rapid arterial calcification.(12) However, this attribute is negated with high
doses of vitamin K, as demonstrated by its ability to result in the regression of arterial calcification. The forms commonly utilized in nutritional supplements are the MK-4 and MK-7.
Although both are effective, MK-4 has a very short half-life,
about one hour, whereas the half-life of MK-7 is much longer,
Brand:
Biotics Research
Product Condition:
New
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